منابع مشابه
Johansen 1..13
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential antiviral therapies. We tested ~2600 approved drugs and molecular probes in an in vitro infection assay using the t...
متن کاملDmd052597 1867..1874
The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite,...
متن کاملDmd059089 1867..1872
Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/ pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn). The influence of both the chemical and physical properties of IgGs has been examined in the context of FcRn interact...
متن کاملThe 1867 Virgin Island Tsunami
The 1867 Virgin Island Tsunami reached large magnitude on the coasts of the Caribbean Islands. A maximum tsunami height of 10 m was reported for two coastal locations (Deshaies and Sainte-Rose) in Guadeloupe. Modelling of the 1867 tsunami is performed in the framework of the nonlinear shallow-water theory. The directivity of the tsunami wave source in the Caribbean Sea according to the assumed ...
متن کاملOp-brhe130268 1931..1932
We have known about the strong association between AS and the HLA-B*27 (B*27) gene for the past 40 years; however, the mechanism with which only some allomorphs of the HLA-B27 molecule, as well as some other HLA class I molecules, are involved in the occurrence of SpAs is still unclear [1]. In this issue of Rheumatology, Cauli et al. [2] present data that may aid our understanding of this mecha...
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ژورنال
عنوان ژورنال: ICES Journal of Marine Science
سال: 1931
ISSN: 1054-3139,1095-9289
DOI: 10.1093/icesjms/6.3.357